Penicitols A-C and penixanacid A from the mangrove-derived Penicillium chrysogenum HDN11-24

J Nat Prod. 2015 Feb 27;78(2):306-10. doi: 10.1021/np500586r. Epub 2015 Jan 22.

Abstract

Three new citrinin analogues, penicitols A-C (1-3), and one new xanthone derivative, penixanacid A (4), together with four known biogenetically related compounds (5-8), were discovered from the extract of a mangrove-derived fungus, Penicillium chrysogenum HND11-24. The structures of penicitols A-C and penixanacid A were established through analysis of extensive spectroscopic data. Their cytotoxic activity against HeLa, BEL-7402, HEK-293, HCT-116, and A549 cell lines was evaluated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents* / chemistry
  • Antineoplastic Agents* / isolation & purification
  • Antineoplastic Agents* / pharmacology
  • China
  • Citrinin* / analogs & derivatives
  • Citrinin* / chemistry
  • Citrinin* / isolation & purification
  • Citrinin* / pharmacology
  • Drug Screening Assays, Antitumor
  • HCT116 Cells
  • HEK293 Cells
  • HeLa Cells
  • Humans
  • Molecular Structure
  • Mycotoxins* / chemistry
  • Mycotoxins* / isolation & purification
  • Mycotoxins* / pharmacology
  • Penicillium chrysogenum / chemistry*
  • Rhizophoraceae / microbiology*
  • Xanthones* / chemistry
  • Xanthones* / isolation & purification
  • Xanthones* / pharmacology

Substances

  • Antineoplastic Agents
  • Mycotoxins
  • Xanthones
  • penicitol A
  • penicitol B
  • penicitol C
  • penixanacid A
  • Citrinin