White, brown, and beige; type 2 immunity gets hot

Maeran Uhm; Alan R Saltiel

doi:10.1016/j.immuni.2015.01.001

White, brown, and beige; type 2 immunity gets hot

Immunity. 2015 Jan 20;42(1):15-7. doi: 10.1016/j.immuni.2015.01.001.

Authors

Maeran Uhm¹, Alan R Saltiel²

Affiliations

¹ Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
² Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: saltiel@umich.edu.

PMID: 25607455
DOI: 10.1016/j.immuni.2015.01.001

Abstract

The biogenesis of beige fat is poorly understood. In recent issues of Nature and Cell, Brestoff et al. (2014) and Lee et al. (2015) demonstrate that resident innate lymphoid cells in subcutaneous fat generate and activate beige adipocytes, producing thermogenesis.

Publication types

Comment

MeSH terms

Adipose Tissue, Brown / metabolism*
Adipose Tissue, White / cytology*
Adipose Tissue, White / immunology*
Animals
Female
Humans
Immunity, Innate / immunology*
Lymphocytes / metabolism*
Lymphocytes / physiology*
Male
Obesity / immunology*