Abstract
A new NHC iridium(I) complex (1) showing significant antiproliferative properties in vitro is described here. Its crystal structure, solution behaviour and interactions with the model proteins cytochrome c (cyt c) and lysozyme were investigated. High resolution ESI-MS measurements suggest that this iridium(i) complex acts as a prodrug and binds cyt c tightly through an unusual "oxidative" mechanism. Eventually, an iridium(III)-NHC fragment is found associated to the protein.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Coordination Complexes / chemistry*
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Coordination Complexes / pharmacology
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Cytochromes c / chemistry
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HEK293 Cells
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HT29 Cells
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Heterocyclic Compounds / chemistry*
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Heterocyclic Compounds / pharmacology
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Humans
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Iridium / chemistry*
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Iridium / pharmacology
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MCF-7 Cells
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Methane / analogs & derivatives*
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Methane / chemistry
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Methane / pharmacology
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Muramidase / chemistry
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Oxidation-Reduction
Substances
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Coordination Complexes
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Heterocyclic Compounds
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carbene
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Iridium
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Cytochromes c
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Muramidase
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Methane