Extensively drug-resistant Acinetobacter baumannii belonging to the international clonal lineage I in a Russian burn intensive care unit

Int J Antimicrob Agents. 2015 May;45(5):525-8. doi: 10.1016/j.ijantimicag.2014.10.017. Epub 2014 Nov 22.

Abstract

The high incidence of mortality in patients with severe burns can be attributed to bloodstream infections caused by drug-resistant microorganisms. Multilocus variable-number tandem repeat analysis (MLVA), multilocus sequence typing (MLST) and class 1 integron PCR amplification were performed to investigate an extensively drug-resistant Acinetobacter baumannii (XDR-AB) strain recovered from a blood culture of a patient admitted to a burn intensive care unit in St Petersburg (Russian Federation). This case study describes an XDR-AB strain of multilocus sequence type ST231 with a blaGES-12 gene cassette encoding a very potent ceftazidimase located inside of a composite class 1 integron. This is the first documented case of XDR-AB belonging to the international clonal lineage I in Russia.

Keywords: Acinetobacter baumannii; Antimicrobial resistance; Bacterial infections; Burn intensive care unit; Class 1 integron; Molecular surveillance.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter Infections / microbiology*
  • Acinetobacter baumannii / classification*
  • Acinetobacter baumannii / drug effects*
  • Acinetobacter baumannii / genetics
  • Acinetobacter baumannii / isolation & purification
  • Aged
  • Anti-Bacterial Agents / pharmacology*
  • Burn Units
  • Burns / complications*
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • Drug Resistance, Multiple, Bacterial*
  • Female
  • Genes, Bacterial
  • Genotype*
  • Humans
  • Integrons
  • Intensive Care Units
  • Minisatellite Repeats
  • Multilocus Sequence Typing
  • Polymerase Chain Reaction
  • Russia

Substances

  • Anti-Bacterial Agents
  • DNA, Bacterial