Mussel-inspired adhesive and transferable free-standing films by self-assembling dexamethasone encapsulated BSA nanoparticles and vancomycin immobilized oxidized alginate

Abstract

This study developed an adhesive and transferable free-standing (FS) film with dual function of osteoinductivity and antibacterial activity, which was obtained by sequentially assembling vancomycin immobilized oxidized sodium alginate and dexamethasone encapsulated chitosan coated BSA nanoparticles on a poly-dopamine layer. The FS films enabled the dual release of vancomycin and dexamethasone. The FS films had excellent osteoinductivity and antibacterial activity by cell culture and antibacterial assay. The FS film was detached from substrates and transferred to non-fouling surfaces by a wet transfer method, which demonstrated that the adhesive FS film is potential to modify biopolymers with non-fouling surfaces in mild and biocompatible conditions for biomedical applications.

Keywords: BSA nanoparticles; Dexamethasone; Free-standing films; Oxidized alginate; Self-assembly; Vancomycin.