Cyclopropanation using flow-generated diazo compounds

Org Biomol Chem. 2015 Mar 7;13(9):2550-4. doi: 10.1039/c5ob00019j.

Abstract

We have devised a room temperature process for the cyclopropanation of electron-poor olefins using unstabilised diazo compounds, generated under continuous flow conditions. This protocol was applied to a wide range of different diazo species to generate functionalised cyclopropanes which are valuable 3D building blocks.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azo Compounds / chemical synthesis*
  • Azo Compounds / chemistry
  • Cyclopropanes / chemistry*
  • Molecular Structure

Substances

  • Azo Compounds
  • Cyclopropanes