Interactions of flavonoids with ionotropic GABA receptors

Jane R Hanrahan; Mary Chebib; Graham A R Johnston

doi:10.1016/bs.apha.2014.10.007

Interactions of flavonoids with ionotropic GABA receptors

Adv Pharmacol. 2015:72:189-200. doi: 10.1016/bs.apha.2014.10.007. Epub 2014 Dec 4.

Authors

Jane R Hanrahan¹, Mary Chebib¹, Graham A R Johnston²

Affiliations

¹ Faculty of Pharmacy, The University of Sydney, Sydney, New South Wales, Australia.
² School of Medical Sciences, Pharmacology, The University of Sydney, Sydney, New South Wales, Australia. Electronic address: graham.johnston@sydney.edu.au.

PMID: 25600371
DOI: 10.1016/bs.apha.2014.10.007

Abstract

In this overview, we highlight some recent advances in the interaction of natural and synthetic flavonoids with ionotropic GABA receptors. Examples of positive, negative, and neutralizing allosteric modulators as well as allosteric agonists are given. Flavonoids appear to act via multiple binding sites on GABA receptors. Unraveling these active sites remains a major task.

Keywords: Flavones; Flavonoids; GABA; Isoflavones; Modulators.

Publication types

Review

MeSH terms

Allosteric Regulation / drug effects
Animals
Binding Sites
Flavonoids / pharmacology*
Humans
Receptors, GABA / drug effects*
Receptors, GABA / metabolism

Substances

Flavonoids
Receptors, GABA