The optimization of essential oils supercritical CO2 extraction from Lavandula hybrida through static-dynamic steps procedure and semi-continuous technique using response surface method

Hossein Kamali; Noushin Aminimoghadamfarouj; Ebrahim Golmakani; Alireza Nematollahi

doi:10.4103/0974-8490.147209

The optimization of essential oils supercritical CO2 extraction from Lavandula hybrida through static-dynamic steps procedure and semi-continuous technique using response surface method

Pharmacognosy Res. 2015 Jan-Mar;7(1):57-65. doi: 10.4103/0974-8490.147209.

Authors

Hossein Kamali¹, Noushin Aminimoghadamfarouj¹, Ebrahim Golmakani², Alireza Nematollahi¹

Affiliations

¹ Research Center of Natural Products Health, North Khorasan University of Medical Sciences, Bojnurd, Iran.
² Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Aim: The aim of this study was to examine and evaluate crucial variables in essential oils extraction process from Lavandula hybrida through static-dynamic and semi-continuous techniques using response surface method.

Materials and methods: Essential oil components were extracted from Lavandula hybrida (Lavandin) flowers using supercritical carbon dioxide via static-dynamic steps (SDS) procedure, and semi-continuous (SC) technique.

Results: Using response surface method the optimum extraction yield (4.768%) was obtained via SDS at 108.7 bar, 48.5°C, 120 min (static: 8×15), 24 min (dynamic: 8×3 min) in contrast to the 4.620% extraction yield for the SC at 111.6 bar, 49.2°C, 14 min (static), 121.1 min (dynamic).

Conclusion: The results indicated that a substantial reduction (81.56%) solvent usage (kg CO2/g oil) is observed in the SDS method versus the conventional SC method.

Keywords: Essential oil; lavandin; lavandula hybrida; response surface method; static-dynamic steps; supercritical carbon dioxide.