A simple modular aptasensor platform utilizing cucurbit[7]uril and a ferrocene derivative as an ultrastable supramolecular linker

Chem Commun (Camb). 2015 Feb 21;51(15):3098-101. doi: 10.1039/c4cc08027k.

Abstract

A simple modular aptamer-based sensor (aptasensor) platform was prepared by combining the merits of the rapid and efficient preparation of a self-assembled monolayer of cucurbit[7]uril (CB[7] SAM) and the strong and specific binding affinity of CB[7] to ferrocenemethylammonium (FA), as an ultrastable supramolecular linker, to immobilize aptamers on CB[7] SAM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aptamers, Nucleotide / chemistry*
  • Biosensing Techniques*
  • Bridged-Ring Compounds / chemistry*
  • DNA / chemistry
  • Ferrous Compounds / chemistry*
  • Gold / chemistry
  • Imidazoles / chemistry*
  • Thrombin / chemistry

Substances

  • Aptamers, Nucleotide
  • Bridged-Ring Compounds
  • Ferrous Compounds
  • Imidazoles
  • cucurbit(7)uril
  • Gold
  • DNA
  • Thrombin