Chromone derivatives from a sponge-derived strain of the fungus Corynespora cassiicola

J Nat Prod. 2015 Feb 27;78(2):286-93. doi: 10.1021/np5009152. Epub 2015 Jan 16.

Abstract

Twelve new chromone derivatives, corynechromones A-L (1-12), were isolated from the sponge-derived fungus Corynespora cassiicola XS-200900I7. Among them, 1/2, 3/4, 5/6, and 7/8 were pairs of epimers. The planar structures were determined by extensive NMR spectroscopic data. The absolute configurations of 1-10 were assigned by the modified Mosher's method and TDDFT ECD calculations together with comparison of their CD spectra. These are the first chromone derivatives reported from the genus Corynespora. A possible rule to determine the absolute configurations at C-2 in chromone derivatives by CD was proposed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Ascomycota / chemistry*
  • Bacillus cereus / drug effects
  • Bacillus subtilis / drug effects
  • Biofouling / prevention & control
  • Cholinesterase Inhibitors / chemistry
  • Cholinesterase Inhibitors / isolation & purification
  • Cholinesterase Inhibitors / pharmacology
  • Chromones / chemistry
  • Chromones / isolation & purification*
  • Chromones / pharmacology
  • Enterococcaceae / drug effects
  • Marine Biology
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Porifera / microbiology*
  • Pseudomonas putida / drug effects
  • Staphylococcus / drug effects
  • Stereoisomerism
  • Topoisomerase I Inhibitors / chemistry
  • Topoisomerase I Inhibitors / isolation & purification
  • Topoisomerase I Inhibitors / pharmacology
  • Vibrio / drug effects

Substances

  • Cholinesterase Inhibitors
  • Chromones
  • Topoisomerase I Inhibitors