Abstract
Twelve new chromone derivatives, corynechromones A-L (1-12), were isolated from the sponge-derived fungus Corynespora cassiicola XS-200900I7. Among them, 1/2, 3/4, 5/6, and 7/8 were pairs of epimers. The planar structures were determined by extensive NMR spectroscopic data. The absolute configurations of 1-10 were assigned by the modified Mosher's method and TDDFT ECD calculations together with comparison of their CD spectra. These are the first chromone derivatives reported from the genus Corynespora. A possible rule to determine the absolute configurations at C-2 in chromone derivatives by CD was proposed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Ascomycota / chemistry*
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Bacillus cereus / drug effects
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Bacillus subtilis / drug effects
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Biofouling / prevention & control
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Cholinesterase Inhibitors / chemistry
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Cholinesterase Inhibitors / isolation & purification
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Cholinesterase Inhibitors / pharmacology
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Chromones / chemistry
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Chromones / isolation & purification*
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Chromones / pharmacology
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Enterococcaceae / drug effects
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Marine Biology
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Porifera / microbiology*
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Pseudomonas putida / drug effects
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Staphylococcus / drug effects
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Stereoisomerism
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Topoisomerase I Inhibitors / chemistry
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Topoisomerase I Inhibitors / isolation & purification
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Topoisomerase I Inhibitors / pharmacology
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Vibrio / drug effects
Substances
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Cholinesterase Inhibitors
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Chromones
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Topoisomerase I Inhibitors