Two perspectives on the origin of the standard genetic code

Orig Life Evol Biosph. 2014 Dec;44(4):287-91. doi: 10.1007/s11084-014-9394-1. Epub 2015 Jan 15.

Abstract

The origin of a genetic code made it possible to create ordered sequences of amino acids. In this article we provide two perspectives on code origin by carrying out simulations of code-sequence coevolution in finite populations with the aim of examining how the standard genetic code may have evolved from more primitive code(s) encoding a small number of amino acids. We determine the efficacy of the physico-chemical hypothesis of code origin in the absence and presence of horizontal gene transfer (HGT) by allowing a diverse collection of code-sequence sets to compete with each other. We find that in the absence of horizontal gene transfer, natural selection between competing codes distinguished by differences in the degree of physico-chemical optimization is unable to explain the structure of the standard genetic code. However, for certain probabilities of the horizontal transfer events, a universal code emerges having a structure that is consistent with the standard genetic code.

MeSH terms

  • Amino Acids / chemistry
  • Amino Acids / metabolism
  • Amino Acyl-tRNA Synthetases / chemistry*
  • Amino Acyl-tRNA Synthetases / metabolism
  • Codon / chemistry*
  • Codon / metabolism
  • Evolution, Molecular
  • Gene Transfer, Horizontal
  • Genes
  • Genetic Code*
  • Models, Genetic
  • Origin of Life*
  • Probability
  • Protein Biosynthesis
  • RNA, Messenger / chemistry*
  • RNA, Messenger / metabolism
  • RNA, Transfer, Amino Acid-Specific / chemistry*
  • RNA, Transfer, Amino Acid-Specific / metabolism
  • Selection, Genetic

Substances

  • Amino Acids
  • Codon
  • RNA, Messenger
  • RNA, Transfer, Amino Acid-Specific
  • Amino Acyl-tRNA Synthetases