Dual responsive dysprosium-doped hydroxyapatite particles and toxicity reduction after functionalization with folic and glucuronic acids

Mater Sci Eng C Mater Biol Appl. 2015 Mar:48:541-7. doi: 10.1016/j.msec.2014.12.033. Epub 2014 Dec 10.

Abstract

The development of probes for biomedical applications demands materials with low toxicity levels besides fluorescence or magnetic properties to be detected by confocal microscopes or MRI resonators. Several drug delivery systems or other biomedical materials prepared with hydroxyapatite have been proposed, however, toxicity effects might arise when the size of particles is nanometric. In this study, hydroxyapatite functionalized with glucuronic or folic acids presented lower oxidative stress, measured from lipoperoxides and nitric oxide indicators in rats than pure hydroxyapatite. In separated experiments, hydroxyapatite was doped with dysprosium cations by coprecipitation producing a single crystal phase with fluorescent properties easily visualized by confocal microscopy when excited at 488nm. These particles also presented the ability to modify the proton relaxation time in T1 maps collected by magnetic resonance imaging. These modified hydroxyapatite nanoparticles could be candidates to design bimodal probes with low toxicity.

Keywords: Fluorescence; Hydroxyapatite; MRI contrast agent; Toxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Durapatite* / adverse effects
  • Durapatite* / chemistry
  • Durapatite* / pharmacokinetics
  • Durapatite* / pharmacology
  • Dysprosium* / adverse effects
  • Dysprosium* / chemistry
  • Dysprosium* / pharmacokinetics
  • Dysprosium* / pharmacology
  • Folic Acid* / adverse effects
  • Folic Acid* / chemistry
  • Folic Acid* / pharmacokinetics
  • Folic Acid* / pharmacology
  • Glucuronic Acid* / adverse effects
  • Glucuronic Acid* / chemistry
  • Glucuronic Acid* / pharmacokinetics
  • Glucuronic Acid* / pharmacology
  • Magnetic Resonance Imaging
  • Microscopy, Fluorescence
  • Oxidative Stress / drug effects
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Dysprosium
  • Glucuronic Acid
  • Durapatite
  • Folic Acid