Successful treatment of a 3-year-old boy with hepatitis-associated aplastic anemia with combination of auto-umbilical cord blood transplantation and immunosuppressive therapy

Transfus Apher Sci. 2015 Apr;52(2):211-3. doi: 10.1016/j.transci.2014.12.021. Epub 2014 Dec 23.

Abstract

In this work we describe a 3-year-old boy with hepatitis-associated aplastic anemia (HAAA) treated successfully with autologous cord blood transplantation combined with immunosuppressive therapy. There is little previous experience in the utility of autologous cord blood transplantation in the treatment of HAAA. Nowadays, for patients born after 1980, an HLA matched sibling donor is not usually available because of the family planning policy in our country. So more and more parents choose to preserve the umbilical cord blood for their children. We consider it a new effective choice for the treatment of HAAA, especially for the pediatric patients.

Keywords: Autologous transplantation; Cord blood; Hepatitis-associated aplastic anemia.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Anemia, Aplastic / complications*
  • Anemia, Aplastic / therapy*
  • Child, Preschool
  • Cord Blood Stem Cell Transplantation / methods*
  • HLA Antigens / chemistry
  • Hepatitis / complications*
  • Hepatitis / therapy*
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Male
  • Remission Induction
  • Transplantation Conditioning / methods
  • Transplantation, Autologous / methods*
  • Treatment Outcome

Substances

  • HLA Antigens
  • Immunosuppressive Agents