Abstract
Blockade of δ-receptors with naltrindole under conditions of systemic immunization abolished the stimulatory effect of β-endorphin (0.0005 μg/kg) on the counts of antibody-producing cells and the titer of antierythrocyte antibodies. Injection of β-endorphin to mice led to stimulation of concanavalin A-induced proliferative activity of splenocytes and IL-4 secretion by the naloxone-dependent mechanism. The peptide did not modify the production of IL-2 and IFN-γ.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Concanavalin A / pharmacology
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Interferon-gamma / metabolism
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Interleukin-2 / metabolism
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Interleukin-4 / metabolism
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Male
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Mice
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Naloxone / pharmacology
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Naltrexone / analogs & derivatives
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Naltrexone / pharmacology
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Receptors, Opioid, delta / antagonists & inhibitors
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Receptors, Opioid, delta / metabolism*
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Spleen / cytology*
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Spleen / drug effects
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beta-Endorphin / pharmacology*
Substances
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Interleukin-2
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Receptors, Opioid, delta
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Concanavalin A
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Interleukin-4
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Naloxone
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Naltrexone
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beta-Endorphin
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Interferon-gamma
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naltrindole