Effects of β-endorphin on functional activity of mouse splenocytes under conditions of in vivo blockade of μ,δ-opioid receptors

Bull Exp Biol Med. 2015 Jan;158(3):356-60. doi: 10.1007/s10517-015-2761-8. Epub 2015 Jan 9.

Abstract

Blockade of δ-receptors with naltrindole under conditions of systemic immunization abolished the stimulatory effect of β-endorphin (0.0005 μg/kg) on the counts of antibody-producing cells and the titer of antierythrocyte antibodies. Injection of β-endorphin to mice led to stimulation of concanavalin A-induced proliferative activity of splenocytes and IL-4 secretion by the naloxone-dependent mechanism. The peptide did not modify the production of IL-2 and IFN-γ.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Concanavalin A / pharmacology
  • Interferon-gamma / metabolism
  • Interleukin-2 / metabolism
  • Interleukin-4 / metabolism
  • Male
  • Mice
  • Naloxone / pharmacology
  • Naltrexone / analogs & derivatives
  • Naltrexone / pharmacology
  • Receptors, Opioid, delta / antagonists & inhibitors
  • Receptors, Opioid, delta / metabolism*
  • Spleen / cytology*
  • Spleen / drug effects
  • beta-Endorphin / pharmacology*

Substances

  • Interleukin-2
  • Receptors, Opioid, delta
  • Concanavalin A
  • Interleukin-4
  • Naloxone
  • Naltrexone
  • beta-Endorphin
  • Interferon-gamma
  • naltrindole