Wheelchair efficiency depends significantly on the individual adjustment of the wheelchair propulsion interface. Wheelchair prescription involves reconfiguring the wheelchair to optimize it for specific user characteristics. Wheelchair tuning procedure is a complicated task that is performed usually by experienced rehabilitation engineers. In this study, we report initial results from the development of a musculoskeletal model of the wheelchair lever propulsion. Such a model could be used for the development of new advanced wheelchair approaches that allow wheelchair designers and practitioners to explore virtually, on a computer, the effects of the intended settings of the lever-propulsion interface. To investigate the lever-propulsion process, we carried out wheelchair lever propulsion experiments where joint angle, lever angle and three-directional forces and moments applied to the lever were recorded during the execution of defined propulsion motions. Kinematic and dynamic features of lever propulsion motions were extracted from the recorded data to be used for the model development. Five healthy male adults took part in these initial experiments. The analysis of the collected kinematic and dynamic motion parameters showed that lever propulsion is realized by a cyclical three-dimensional motion of upper extremities and that joint torque for propulsion is maintained within a certain range. The synthesized propulsion model was verified by computer simulation where the measured lever-angles were compared with the angles generated by the developed model simulation. Joint torque amplitudes were used to impose the torque limitation to the model joints. The results evidenced that the developed model can simulate successfully basic lever propulsion tasks such as pushing and pulling the lever.