This study presents an active brace which is a cost efficient precision-controlled advanced therapy medicinal product for time and rate controlled transdermal drug delivery (TDD) through the use of drug containing nanoparticles and electronics. The active brace is designed to adjust the pressure at the contact area where the medication is applied. The drug is contained in the nanoparticles produced and takes effect when the nanoparticles burst under pressure. The brace is designed to be compact and wearable which can be preprogrammed by a specialist to continue treatment sessions outside the medical facilities providing convenience and comfort to the patient.