Predictors of hyperlipidemia during the first half of pregnancy in Mexican women

Nutr Hosp. 2014 Oct 18;31(1):508-13. doi: 10.3305/nh.2015.31.1.7608.

Abstract
in English, Spanish

Objective: To determine the predictors of hypercholesterolemia and of hypertriglyceridemia during the first half of pregnancy in Mexican women.

Methods: Cross-sectional comparative study of pregnant women with less than 21 weeks of gestational age.

Measurements: Demographic information, obstetric history, prepregnancy body mass index, cholesterol and triglycerides. Cross tabulations and multiple logistic regression were used for statistical analysis.

Results: 230 participants; 61 women with normal prepregnancy body mass index, 108 with overweight, and 61 with obesity. Dyslipidemia was defined as elevated cholesterol (>180 mg/dL) or triglycerides (>170 mg/dL). After adjusting by potential confounders, independent predictors of hypercholesterolemia included being overweight (OR=2.8, 95% CI 1.4-5.9), being obese (OR=3.7 95% CI 1.6-8.4) or being on the second trimester of pregnancy. The same predictors were found for hypertriglyceridemia, respectively OR=2.8, 95% CI 1.4-5.6, OR=2.9, 95% CI 1.3-6.5, OR=2.6, 95% CI 1.4-4.7.

Conclusion: Mexican women with prepregnancy overweight or obesity have greater risk of suffering hypercholesterolemia and hypertriglyceridemia during pregnancy. Women in the second trimester had higher levels of both lipids as compared to the first one. This is the first Mexican study that confirms the increase of lipids as gestational age progresses.

Objetivo: Determinar los predictores de hipercolesterolemia y de hipertrigliceridemia durante la primera mitad del embarazo en mujeres Mexicanas. Métodos: Estudio transversal comparativo de mujeres embarazadas con menos de 21 semanas de edad gestacional. Mediciones: información demográfica, historia obstétrica, índice de masa corporal pregestacional, niveles sanguíneos de colesterol y triglicéridos. Se usaron tabulaciones cruzadas y regresión logística múltiple en el análisis estadístico. Resultados: 230 participantes; 61 mujeres con índice de masa corporal pregestacional normal, 108 con sobrepeso, y 61 con obesidad. Dislipidemia se definió como elevación de colesterol (>180 mg/dL) ó triglicéridos (>170 mg/dL). Después de ajustar con potenciales variables de confusión, los predictores independientes de hipercolesterolemia incluyeron sobrepeso (OR=2.8, 95% CI 1.4-5.9), obesidad (OR=3.7 95% CI 1.6-8.4) o estar en el segundo trimestre del embarazo. Los mismos predictores se encontraron para hipertrigliceridemia, respectivamente: OR=2.8, 95% CI 1.4-5.6, OR=2.9, 95% CI 1.3-6.5, OR=2.6, 95% CI 1.4-4.7. Conclusión: Mujeres Mexicanas con sobrepeso u obesidad pregestacional tienen mayor riesgo de presentar hipercolesterolemia e hipertrigliceridemia durante el embarazo. Mujeres en el segundo trimestre tuvieron niveles más altos de ambos lípidos comparando con el primer trimestre. Este es el primer estudio Mexicano que confirma el incremento de lípidos conforme la edad gestacional progresa.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Cross-Sectional Studies
  • Female
  • Humans
  • Hyperlipidemias / etiology*
  • Lipids / blood
  • Mexico
  • Obesity / complications
  • Overweight / complications
  • Pregnancy
  • Pregnancy Complications, Cardiovascular / etiology*
  • Pregnancy Trimester, Second
  • Pregnancy Trimester, Third
  • Risk Factors
  • Triglycerides / blood
  • Young Adult

Substances

  • Lipids
  • Triglycerides