CDK6 is a regulator of stem cells "Egr" to wake up

Blood. 2015 Jan 1;125(1):7-9. doi: 10.1182/blood-2014-11-609230.

Abstract

In this issue of Blood, Scheicher et al show that cyclin-dependent kinase 6 (CDK6) has a novel role in the regulation of both normal and leukemic stem cells. It acts as a transcriptional suppressor of Egr1, enabling it to control both normal and leukemic stem cell activation.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cyclin-Dependent Kinase 6 / physiology*
  • Early Growth Response Protein 1 / metabolism*
  • Hematopoiesis / physiology*
  • Hematopoietic Stem Cells / cytology*
  • Leukemia / metabolism*

Substances

  • Early Growth Response Protein 1
  • Egr1 protein, mouse
  • Cdk6 protein, mouse
  • Cyclin-Dependent Kinase 6