Abstract
In this issue of Blood, Scheicher et al show that cyclin-dependent kinase 6 (CDK6) has a novel role in the regulation of both normal and leukemic stem cells. It acts as a transcriptional suppressor of Egr1, enabling it to control both normal and leukemic stem cell activation.
MeSH terms
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Animals
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Cyclin-Dependent Kinase 6 / physiology*
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Early Growth Response Protein 1 / metabolism*
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Hematopoiesis / physiology*
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Hematopoietic Stem Cells / cytology*
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Leukemia / metabolism*
Substances
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Early Growth Response Protein 1
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Egr1 protein, mouse
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Cdk6 protein, mouse
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Cyclin-Dependent Kinase 6