Trombose intracardíaca na doença de Behçet: evento com risco de vida

Pedro Madureira; Mariana Rodrigues; Edite Serrano; Artur Bonito Vítor; Iva Brito

doi:10.1016/j.rbr.2014.11.001

Trombose intracardíaca na doença de Behçet: evento com risco de vida

Rev Bras Reumatol. 2014 Dec 23:S0482-5004(14)00245-9. doi: 10.1016/j.rbr.2014.11.001. Online ahead of print.

[Article in Portuguese]

Authors

Pedro Madureira¹, Mariana Rodrigues², Edite Serrano³, Artur Bonito Vítor², Iva Brito⁴

Affiliations

¹ Serviço de Reumatologia, Centro Hospitalar de São João, Porto, Portugal; Departamento de Reumatologia, Faculdade de Medicina do Porto, Porto, Portugal. Electronic address: pmsmadureira@gmail.com.
² Departamento de Pediatria, Centro Hospitalar de São João, Porto, Portugal.
³ Cardiologia Pediátrica, Centro Hospitalar de São João, Porto, Portugal.
⁴ Serviço de Reumatologia, Centro Hospitalar de São João, Porto, Portugal; Departamento de Reumatologia, Faculdade de Medicina do Porto, Porto, Portugal; Departamento de Pediatria, Centro Hospitalar de São João, Porto, Portugal.

PMID: 25553854
DOI: 10.1016/j.rbr.2014.11.001

Abstract

An adolescent with a recent diagnostic of Behçet's Disease (BD) was admitted with fever and intracardiac lesions detected on a routine transthoracic echocardiography, suggestive of endocarditis. Due to the absence of improvement after several rounds of antibiotics the patient was submitted to contrast-enhanced cardiac MRI that showed signs of intracardiac thrombosis, superior vena cava syndrome and pulmonary thromboembolism. The patient underwent surgery to excise the lesions and has been treated with cyclophosphamide and high dose prednisolone achieving complete remission. Intracardiac thrombosis is a rare manifestation of BD, and is associated with a poor prognosis. These patients usually require a combination of anticoagulation and immunosuppression to achieve remission.

Keywords: Anticoagulantes; Anticoagulation; Behçet's disease; Ciclofosfamida; Cyclophosphamide; Doença de Behçet; Intracardiac thrombosis; Superior vena cava syndrome; Síndrome da veia cava superior; Trombose intracardíaca.