Control of hair cell development by molecular pathways involving Atoh1, Hes1 and Hes5

Gene. 2015 Mar 1;558(1):6-24. doi: 10.1016/j.gene.2014.12.054. Epub 2014 Dec 28.

Abstract

Atoh1, Hes1 and Hes5 are crucial for normal inner ear hair cell development. They regulate the expression of each other in a complex network, while they also interact with many other genes and pathways, such as Notch, FGF, SHH, WNT, BMP and RA. This paper summarized molecular pathways that involve Atoh1, Hes1, and Hes5. Some of the pathways and gene regulation mechanisms discussed here were studied in other tissues, yet they might inspire studies in inner ear hair cell development. Thereby, we presented a complex regulatory network involving these three genes, which might be crucial for proliferation and differentiation of inner ear hair cells.

Keywords: Atoh1; Hair cell; Hes1; Hes5; Inner ear.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Basic Helix-Loop-Helix Transcription Factors / genetics
  • Basic Helix-Loop-Helix Transcription Factors / metabolism*
  • Cell Proliferation
  • Gene Expression Regulation, Developmental
  • Gene Regulatory Networks*
  • Hair Cells, Auditory / cytology*
  • Hair Cells, Auditory / physiology*
  • Homeodomain Proteins / metabolism*
  • Humans
  • Signal Transduction

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • Homeodomain Proteins