Ruthenium-catalyzed reductive amination without an external hydrogen source

Pavel N Kolesnikov; Niyaz Z Yagafarov; Dmitry L Usanov; Victor I Maleev; Denis Chusov

doi:10.1021/ol503595m

Ruthenium-catalyzed reductive amination without an external hydrogen source

Org Lett. 2015 Jan 16;17(2):173-5. doi: 10.1021/ol503595m. Epub 2014 Dec 31.

Authors

Pavel N Kolesnikov¹, Niyaz Z Yagafarov, Dmitry L Usanov, Victor I Maleev, Denis Chusov

Affiliation

¹ A. N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences, 119991, Vavilova St. 28, Moscow, Russian Federation.

PMID: 25549756
DOI: 10.1021/ol503595m

Abstract

A ruthenium-catalyzed reductive amination without an external hydrogen source has been developed using carbon monoxide as the reductant and ruthenium(III) chloride (0.008-2 mol %) as the catalyst. The method was applied to the synthesis of antianxiety agent ladasten.