Abstract
The sol-gel process provides a robust and versatile technology for the immobilization of biologicals. A wide range of inorganic, composites and hybrid materials can be prepared to encapsulate molecular drugs, proteins, antibodies/antigens, enzymes, nucleic acids, prokaryotic and eukaryotic cells into bulk gels, particles and films. This review describes the applications of sol-gel encapsulation relevant to medicinal chemistry focusing on the recent development of biosensors as well as systems for production, screening and delivery of bioactive compounds and biomaterials.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / metabolism
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Biosensing Techniques / methods*
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Cells, Immobilized
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Chemistry, Pharmaceutical / methods*
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Delayed-Action Preparations
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Drug Carriers / chemical synthesis
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Drug Carriers / chemistry
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Drug Compounding / methods*
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Gels
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Humans
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Immobilized Proteins / chemistry*
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Nanoparticles / chemistry
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Phase Transition*
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Silicon Dioxide / chemistry
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Tissue Engineering
Substances
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Anti-Bacterial Agents
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Delayed-Action Preparations
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Drug Carriers
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Gels
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Immobilized Proteins
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Silicon Dioxide