Molecularly imprinted sol-gel materials for medical applications

Curr Top Med Chem. 2015;15(3):199-222. doi: 10.2174/1568026614666141229112246.

Abstract

The present review deals with the sol-gel imprinting of both drug and non-drug templates of medical relevance, namely neurotransmitters, biomarkers, hormones, proteins and cells. Nearly a hundred recent works, either developmental or applied in a medical-related context, were critically analyzed. It may be concluded that, although research is still at an early stage, the potential of these sol-gel materials was well demonstrated in a few applications of critical interest for medicinal/biomedical science. The vast room left for expansion and improvement envisages a continuously growing interest by researchers in the future, eventually resulting in important medical applications able to enter the professional and consumer medical markets.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / metabolism
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / metabolism
  • Biomarkers / chemistry
  • Biomarkers / metabolism
  • Cells, Immobilized
  • Chemistry, Pharmaceutical / methods*
  • Drug Carriers / chemical synthesis
  • Drug Carriers / chemistry
  • Hormones / chemistry
  • Hormones / metabolism
  • Humans
  • Molecular Imprinting / methods*
  • Nafcillin / chemistry
  • Nafcillin / metabolism
  • Neurotransmitter Agents / chemistry
  • Neurotransmitter Agents / metabolism
  • Phase Transition*
  • Psychotropic Drugs / chemistry
  • Psychotropic Drugs / metabolism
  • Quaternary Ammonium Compounds / chemistry
  • Siloxanes / chemistry

Substances

  • Anti-Bacterial Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Biomarkers
  • Drug Carriers
  • Hormones
  • Neurotransmitter Agents
  • Psychotropic Drugs
  • Quaternary Ammonium Compounds
  • Siloxanes
  • Nafcillin