Impact of Comorbidities on Prostate Cancer Stage at Diagnosis in Florida

Am J Mens Health. 2016 Jul;10(4):285-95. doi: 10.1177/1557988314564593. Epub 2014 Dec 26.

Abstract

To examine the association of major types of comorbidity with late-stage prostate cancer, a random sample of 11,083 men diagnosed with prostate cancer during 2002-2007 was taken from the Florida Cancer Data System. Individual-level covariates included demographics, primary insurance payer, and comorbidity following the Elixhauser Index. Socioeconomic variables were extracted from Census 2000 data and merged to the individual level data. Provider-to-case ratio at county level was alsocomputed. Multilevel logistic regression was used to assess associations between these factors and late-stage diagnosis of prostate cancer. Higher odds of late-stage diagnosis was significantly related to presence of comorbidities, being unmarried, current smoker, uninsured, and diagnosed in not-for-profit hospitals. The study reported that the presence of certain comorbidities, specifically 10 out of the 45, was associated with late-stage prostate cancer diagnosis. Eight out of 10 significant comorbid conditions were associated with greater risk of being diagnosed at late-stage prostate cancer. On the other hand, men who had chronic pulmonary disease, and solid tumor without metastasis, were less likely to be diagnosed with late-stage prostate cancer. Late-stage diagnosis was associated with comorbidity, which is often associated with increased health care utilization. The association of comorbidity with late-stage prostate cancer diagnosis suggests that individuals with significant comorbidity should be offered routine screening for prostate cancer rather than focusing only on managing symptomatic health problems.

Keywords: comorbidity; health care utilization; health inequality/disparity; health screening; prostate cancer.

MeSH terms

  • Adult
  • Aged
  • Black or African American / statistics & numerical data
  • Comorbidity
  • Databases, Factual
  • Delayed Diagnosis / adverse effects*
  • Delayed Diagnosis / economics
  • Florida / epidemiology
  • Health Status Disparities
  • Healthcare Disparities / economics*
  • Healthcare Disparities / ethnology
  • Humans
  • Incidence
  • Insurance, Health / classification
  • Insurance, Health / economics
  • Life Style
  • Logistic Models
  • Male
  • Marital Status
  • Middle Aged
  • Multilevel Analysis
  • Neoplasm Staging
  • Prostatic Neoplasms / diagnosis*
  • Prostatic Neoplasms / economics
  • Prostatic Neoplasms / ethnology
  • Prostatic Neoplasms / mortality
  • Registries
  • Severity of Illness Index
  • Social Determinants of Health / economics*
  • Social Determinants of Health / ethnology
  • White People / statistics & numerical data