Future alternatives for the treatment of infections caused by carbapenemase-producing Enterobacteriaceae: what is in the pipeline?

Enferm Infecc Microbiol Clin. 2014 Dec:32 Suppl 4:56-60. doi: 10.1016/S0213-005X(14)70175-2.

Abstract

The emergence and spread of carbapenemase-producing Enterobacteriaceae is an important and very concerning problem. There is an urgent need of new antibimicrobials for treating these infections. Currently there are some options in the pipeline. Several new beta-lactamase and carbapenemase inhibitors as avibactam and MK-7655, combined with old or new betalactams are a very interesting option. Some combinations as ceftazidime-avibactam are in the late stages of clinical development and could reach the market in the next years. New aminoglycosides as plazomicin, tetracycline derivates as eravacycline, and several other new molecules as monosulfactams are currently in different stages of development.

Keywords: Avibactam; BAL-30072; Beta-lactamase inhibitors; Biapenem/RPX7009; Eravacilina; Eravacycline; Inhibidores de betalactamasas; Plazomicin; Plazomicina.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-Bacterial Agents / metabolism
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use*
  • Bacterial Proteins / antagonists & inhibitors
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Carbapenems / metabolism
  • Carbapenems / therapeutic use
  • Clinical Trials as Topic
  • Drug Evaluation, Preclinical
  • Drug Resistance, Multiple, Bacterial* / genetics
  • Drug Therapy, Combination
  • Drugs, Investigational / metabolism
  • Drugs, Investigational / pharmacology
  • Drugs, Investigational / therapeutic use*
  • Enterobacteriaceae / drug effects
  • Enterobacteriaceae / enzymology*
  • Enterobacteriaceae / genetics
  • Enterobacteriaceae Infections / drug therapy*
  • Enterobacteriaceae Infections / epidemiology
  • Enterobacteriaceae Infections / microbiology
  • Forecasting
  • Humans
  • beta-Lactam Resistance* / genetics
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Carbapenems
  • Drugs, Investigational
  • beta-Lactamases
  • carbapenemase