Oseltamivir-resistant influenza A(H1N1)pdm09 viruses, United States, 2013-14

Emerg Infect Dis. 2015 Jan;21(1):136-41. doi: 10.3201/eid2101.141006.

Abstract

We report characteristics of oseltamivir-resistant influenza A(H1N1)pdm09 viruses and patients infected with these viruses in the United States. During 2013-14, fifty-nine (1.2%) of 4,968 analyzed US influenza A(H1N1)pdm09 viruses had the H275Y oseltamivir resistance-conferring neuraminidase substitution. Our results emphasize the need for local surveillance for neuraminidase inhibitor susceptibility among circulating influenza viruses.

MeSH terms

  • Adolescent
  • Adult
  • Antiviral Agents / pharmacology*
  • Drug Resistance, Viral
  • Female
  • Humans
  • Influenza A Virus, H1N1 Subtype / drug effects*
  • Influenza A Virus, H1N1 Subtype / enzymology
  • Influenza A Virus, H1N1 Subtype / genetics
  • Influenza, Human / drug therapy
  • Influenza, Human / epidemiology
  • Influenza, Human / virology*
  • Male
  • Middle Aged
  • Neuraminidase / genetics
  • Oseltamivir / pharmacology*
  • Phylogeny
  • Prevalence
  • United States / epidemiology
  • Viral Proteins / genetics
  • Young Adult

Substances

  • Antiviral Agents
  • Viral Proteins
  • Oseltamivir
  • Neuraminidase