Electronic structure of antibiotic erythromycin

Igor Novak; Branka Kovač

doi:10.1016/j.saa.2014.11.076

Electronic structure of antibiotic erythromycin

Spectrochim Acta A Mol Biomol Spectrosc. 2015 Mar 5:138:550-2. doi: 10.1016/j.saa.2014.11.076. Epub 2014 Dec 11.

Authors

Igor Novak¹, Branka Kovač²

Affiliations

¹ Charles Sturt University, POB 883, Orange, NSW 2800, Australia. Electronic address: inovak@csu.edu.au.
² Physical Chemistry Division, "R. Bošković" Institute, HR-10000 Zagreb, Croatia. Electronic address: bkovac@irb.hr.

PMID: 25528514
DOI: 10.1016/j.saa.2014.11.076

Abstract

The electronic structure of erythromycin A (ERYMA) molecule has been studied by UV photoelectron spectroscopy and assigned (in the low ionization energy region only) by empirical arguments. The two orbitals with highest energy (lowest ionization energy) are localized on the nitrogen of the desosamine sugar functional group and on the ester group of macrolide (lactone) ring. We discuss how these orbital energies can help to rationalize the known mode of binding of ERYMA to their biological receptors.

Keywords: Erythromycin; Photoelectron spectroscopy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemistry
Electrons*
Erythromycin / chemistry*
Erythromycin / pharmacology
Light

Substances

Anti-Bacterial Agents
Erythromycin