Blood HCO3- concentration predicts the long-term prognosis of acute kidney injury patients

Biomark Med. 2014;8(10):1219-26. doi: 10.2217/bmm.14.91.

Abstract

Aim: To evaluate the value of HCO3(-) concentrations in long-term prognosis after acute kidney injury.

Patients & methods: A total of 169 AKI patients were included in this study. At the 12-month follow-up, the patients were divided into recovered and unrecovered groups.

Results: The blood HCO3(-) concentrations were significantly correlated with poor prognosis. The area under the curve for renal prognosis of 6 months later blood HCO3(-) concentrations was 0.798. Combined HCO3(-) and Scr level area under the curve was 0.952.

Conclusion: The blood HCO3(-) level was useful in evaluating renal prognosis of acute kidney injury patients. The combination of blood HCO3(-) concentration and Scr level increased the accuracy of prediction.

Keywords: Cox regression analysis; Kaplan–Meier method; acute kidney injury (AKI); blood HCO3 - concentration; combined markers; follow-up; prevention; receiver operating characteristic–area under the curve; renal prognosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Kidney Injury / blood*
  • Acute Kidney Injury / diagnosis
  • Adult
  • Bicarbonates / blood*
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Prognosis
  • Young Adult

Substances

  • Bicarbonates