Targeting innate immunity for treatment of type 1 diabetes

Immunotherapy. 2014;6(12):1239-42. doi: 10.2217/imt.14.96.
No abstract available

Keywords: TLR4; Type 1 diabetes; immune tolerization; innate immune therapy; reversal of Type 1 diabetes.

Publication types

  • Editorial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adaptive Immunity / drug effects
  • Animals
  • Antibodies, Monoclonal / therapeutic use*
  • Diabetes Mellitus, Type 1 / immunology
  • Diabetes Mellitus, Type 1 / therapy*
  • Disease Models, Animal
  • Humans
  • Hygiene Hypothesis
  • Immunity, Innate* / drug effects
  • Inflammation Mediators / metabolism
  • Insulin-Secreting Cells / drug effects*
  • Insulin-Secreting Cells / immunology
  • Mice, Inbred NOD
  • Mice, Knockout
  • Molecular Targeted Therapy
  • Myeloid Differentiation Factor 88 / metabolism
  • Toll-Like Receptor 4 / genetics
  • Toll-Like Receptor 4 / immunology
  • Toll-Like Receptor 4 / metabolism*

Substances

  • Antibodies, Monoclonal
  • Inflammation Mediators
  • Myeloid Differentiation Factor 88
  • TLR4 protein, human
  • Toll-Like Receptor 4