Bilateral thalamic stimulation induces insomnia in patients treated for intractable tremor

Abstract

Study objectives: To explore the influence of acute bilateral ventral intermediate thalamic nucleus (VIM) stimulation on sleep.

Design: Three consecutive full-night polysomnography recordings were made in the laboratory. After the habituation night, a random order for night ON-stim and OFF-stim was applied for the second and third nights.

Setting: Sleep disorders unit of a university hospital.

Patients: Eleven patients with bilateral stimulation of the ventral intermediate nucleus of the thalamus (VIM) for drug-resistant tremor.

Measurements: Sleep measures on polysomnography.

Results: Total sleep time was reduced during night ON-stim compared to OFF- stim, as well as rapid eye movement sleep percentage while the percentage of N2 increased. Wakefulness after sleep onset time was increased.

Conclusion: Our results show that bilateral stimulation of the VIM nuclei reduces sleep and could be associated with insomnia.

Keywords: adverse event; deep brain stimulation; insomnia; sleep.