Characterization of 5' truncated transposed copies of the I factor in Drosophila melanogaster

Nucleic Acids Res. 1989 Sep 12;17(17):6939-45. doi: 10.1093/nar/17.17.6939.

Abstract

I factors in Drosophila melanogaster are transposable elements structurally related to Mammalian LINEs. Their transposition is activated at high frequencies during I-R hybrid dysgenesis and is associated with the production of mutations of various sorts. Very few of these mutations have been studied at the molecular level; those reported so far result either from chromosomal rearrangements or from insertions of complete I factors. We have analysed three I-R induced yellow mutations and have found that one of them is due to the insertion of an I element very similar to the complete I factor, whereas the other two are due to insertions of I elements that are truncated at their 5' ends; one of them exhibits an unusual 3' end. We discuss possible mechanisms of production of such modified I elements.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromosomes / ultrastructure
  • DNA Transposable Elements*
  • Drosophila melanogaster / genetics*
  • Female
  • Male
  • Mutation
  • Repetitive Sequences, Nucleic Acid

Substances

  • DNA Transposable Elements