The adrenal medulla, not CB1 receptors, mediates the inhibitory effect of acute transverse aortic constriction on the neurogenic vasopressor response

Piotr Karabowicz; Eberhard Schlicker; Anna Pędzińska-Betiuk; Monika Kloza; Barbara Malinowska

doi:10.1016/j.lfs.2014.11.032

The adrenal medulla, not CB1 receptors, mediates the inhibitory effect of acute transverse aortic constriction on the neurogenic vasopressor response

Life Sci. 2015 Oct 1:138:86-93. doi: 10.1016/j.lfs.2014.11.032. Epub 2014 Dec 11.

Authors

Piotr Karabowicz¹, Eberhard Schlicker², Anna Pędzińska-Betiuk¹, Monika Kloza¹, Barbara Malinowska³

Affiliations

¹ Department of Experimental Physiology and Pathophysiology, Medical University of Białystok, Mickiewicz str. 2A, 15-222 Białystok, Poland.
² Department of Pharmacology and Toxicology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.
³ Department of Experimental Physiology and Pathophysiology, Medical University of Białystok, Mickiewicz str. 2A, 15-222 Białystok, Poland. Electronic address: bmalin@umb.edu.pl.

PMID: 25498898
DOI: 10.1016/j.lfs.2014.11.032

No abstract available

Keywords: AM251 (PubChem CID: 2125); CP55940 (PubChem CID: 104895); Cannabinoid receptors; Glibenclamide (CID:3488); K(ATP) channels; Pithed rat; Pressure overload; Rauwolscine hydrochloride (PubChem CID: 197067); α(2)-Adrenoceptors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adrenal Medulla / pathology*
Animals
Autonomic Fibers, Preganglionic / drug effects
Blood Pressure / drug effects*
Constriction, Pathologic / pathology*
Electric Stimulation
Heart Rate / drug effects
Male
Myocardial Contraction / drug effects
Phenylephrine / pharmacology
Rats
Rats, Wistar
Receptor, Cannabinoid, CB1 / agonists
Receptor, Cannabinoid, CB1 / antagonists & inhibitors
Receptor, Cannabinoid, CB1 / drug effects*
Vasopressins / pharmacology

Substances

Receptor, Cannabinoid, CB1
Vasopressins
Phenylephrine