Non-random distribution of 17 Y-chromosome STR loci in different areas of Sardinia

R Robledo; A Mameli; C M Scudiero; G Vona; L Corrias; V Bachis; C Culigioni; C M Calò

doi:10.1016/j.fsigen.2014.11.019

Non-random distribution of 17 Y-chromosome STR loci in different areas of Sardinia

Forensic Sci Int Genet. 2015 May:16:26-28. doi: 10.1016/j.fsigen.2014.11.019. Epub 2014 Nov 30.

Authors

R Robledo¹, A Mameli², C M Scudiero³, G Vona⁴, L Corrias⁵, V Bachis⁶, C Culigioni⁷, C M Calò⁸

Affiliations

¹ Department of Biomedical Sciences, University of Cagliari, Italy. Electronic address: rrobledo@unica.it.
² Reparto Investigazioni Scientifiche, Carabinieri di Cagliari, Italy. Electronic address: alessandro.mameli@carabinieri.it.
³ Reparto Investigazioni Scientifiche, Carabinieri di Cagliari, Italy. Electronic address: carmine.scudiero@carabinieri.it.
⁴ Department of Life and Environmental Sciences, University of Cagliari, Italy. Electronic address: vona@unica.it.
⁵ Department of Life and Environmental Sciences, University of Cagliari, Italy. Electronic address: laura.corrias@hotmail.it.
⁶ Department of Life and Environmental Sciences, University of Cagliari, Italy. Electronic address: vbachis@unica.it.
⁷ Department of Life and Environmental Sciences, University of Cagliari, Italy. Electronic address: cla.culigioni@unica.it.
⁸ Department of Life and Environmental Sciences, University of Cagliari, Italy. Electronic address: cmcalo@unica.it.

PMID: 25498479
DOI: 10.1016/j.fsigen.2014.11.019

Abstract

Allele frequencies of 17 Y-chromosome short tandem repeat (STR) loci, included in the AmpFlSTR® Y-FilerTM amplification kit, were analyzed for the first time in different samplings (N=268) from Sardinia, Italy. Samples were collected from three isolated populations (N=139) and three open populations (N=129). A total of 230 unique haplotypes were detected; the observed haplotype diversity and discrimination capacity were 0.998 and 0.858, respectively. The data presented confirm that Sardinian population is well differentiated from other Italian and Mediterranean populations. Although regarded as a homogeneous population, substantial heterogeneity was detected when Sardinian isolated villages or microareas were analyzed. Our results highlights the importance of building a Sardinia-own database, organized by small areas, as a powerful tool for both forensic applications and population genetics studies.

Keywords: Haplotype; Isolated populations; Sardinia; Y-STRs.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosomes, Human, Y*
Ethnicity / genetics*
Gene Frequency
Genes, Y-Linked*
Genetics, Population
Haplotypes
Humans
Italy
Male
Microsatellite Repeats*