Multivalent glycocyclopeptides: toward nano-sized glycostructures

Abstract

Cyclopeptides have recently emerged as attractive molecular scaffolds for the multivalent presentation of carbohydrates in a well-defined constrained spatial orientation. This mini-review describes the last advances on the synthesis and the biological applications of these particular structures, going from low molecular weight glycoclusters to fully synthetic nano-sized glycodendrimers.

Keywords: Carbohydrate–protein interaction; Cyclopeptide; Glycocluster; Glycodendrimer; Lectin; Multivalency.