Abstract
The effect of repeated treatment with imipramine, citalopram and ECS on the density of alpha 1-adrenoceptors in the cerebral cortex of rats with a dopaminergic lesion was studied. Imipramine and citalopram produced alph 1-upregulation in normal animals but not in animals with a dopaminergic lesion. On the other hand, ECS, produced such an effect in both normal and lesioned rats. Our results indicate that the investigated drugs (imipramine, citalopram) and ECS induce alpha 1-up-regulation via different mechanisms, and that the effect of these drugs depends on intact dopaminergic nerve terminals.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antidepressive Agents / pharmacology*
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Cerebral Cortex / drug effects
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Cerebral Cortex / metabolism*
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Citalopram / pharmacology
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Dopamine / physiology*
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Electroshock*
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Hydroxydopamines / pharmacology
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Imipramine / pharmacology
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Male
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Nerve Endings / drug effects
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Nerve Endings / physiology*
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Norepinephrine / metabolism
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Oxidopamine
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Rats
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Rats, Inbred Strains
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Receptors, Adrenergic, alpha / drug effects
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Receptors, Adrenergic, alpha / metabolism*
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Serotonin / metabolism
Substances
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Antidepressive Agents
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Hydroxydopamines
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Receptors, Adrenergic, alpha
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Citalopram
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Serotonin
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Oxidopamine
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Imipramine
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Dopamine
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Norepinephrine