Functionalisation of Ti6Al4V components fabricated using selective laser melting with a bioactive compound

Jayasheelan Vaithilingam; Samuel Kilsby; Ruth D Goodridge; Steven D R Christie; Steve Edmondson; Richard J M Hague

doi:10.1016/j.msec.2014.10.015

Functionalisation of Ti6Al4V components fabricated using selective laser melting with a bioactive compound

Mater Sci Eng C Mater Biol Appl. 2015 Jan:46:52-61. doi: 10.1016/j.msec.2014.10.015. Epub 2014 Oct 5.

Authors

Jayasheelan Vaithilingam¹, Samuel Kilsby², Ruth D Goodridge³, Steven D R Christie², Steve Edmondson⁴, Richard J M Hague¹

Affiliations

¹ Additive Manufacturing and 3D Printing Research Group, School of Engineering, The University of Nottingham, Nottingham NG7 2RD, UK.
² Department of Chemistry, Loughborough University, Loughborough LE11 3TU, UK.
³ Additive Manufacturing and 3D Printing Research Group, School of Engineering, The University of Nottingham, Nottingham NG7 2RD, UK. Electronic address: Ruth.Goodridge@nottingham.ac.uk.
⁴ School of Materials, The University of Manchester, Manchester M13 9PL, UK.

PMID: 25491959
DOI: 10.1016/j.msec.2014.10.015

Abstract

Surface modification of an implant with a biomolecule is used to improve its biocompatibility and to reduce post-implant complications. In this study, a novel approach has been used to functionalise phosphonic acid monolayers with a drug. Ti6Al4V components fabricated using selective laser melting (SLM) were functionalised with Paracetamol (a pharmaceutically relevant biomolecule) using phosphonic acid based self-assembled monolayers (SAMs). The attachment, stability of the monolayers on the SLM fabricated surface and functionalisation of SAMs with Paracetamol were studied using X-ray photoelectron spectroscopy (XPS) and surface wettability measurements. The obtained results confirmed that SAMs were stable on the Ti6Al4V surface for over four weeks and then began to desorb from the surface. The reaction used to functionalise the phosphonic acid monolayers with Paracetamol was noted to be successful. Thus, the proposed method has the potential to immobilise drugs/proteins to SAM coated surfaces and improve their biocompatibility and reduce post-implant complications.

Keywords: Additive manufacturing; Functionalisation; Selective laser melting (SLM); Self-assembled monolayers (SAMs); X-ray photoelectron spectroscopy (XPS).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetaminophen
Alloys
Coated Materials, Biocompatible / chemistry*
Drug Stability
Lasers*
Photoelectron Spectroscopy
Surface Properties
Titanium / chemistry*

Substances

Alloys
Coated Materials, Biocompatible
titanium alloy (TiAl6V4)
Acetaminophen
Titanium