Abstract
Due to rapidly increasing resistance development against conventional antibiotics, as well as problems associated with diseases either triggered or deteriorated by infection, antimicrobial and anti-inflammatory peptides have attracted considerable interest during the last few years. While there is an emerging understanding of the direct antimicrobial function of such peptides through bacterial membrane destabilization, the mechanisms of their anti-inflammatory function are less clear. We here summarize some recent results obtained from our own research on anti-inflammatory peptides, with focus on peptide-(lipo)polysaccharide interactions.
Keywords:
Anti-inflammatory; Antimicrobial; Lipid A; Lipopolysaccharide; Peptide.
Copyright © 2014 Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / immunology
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Anti-Infective Agents / pharmacology*
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / immunology
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Anti-Inflammatory Agents / pharmacology*
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Antimicrobial Cationic Peptides / chemistry
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Antimicrobial Cationic Peptides / immunology
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Antimicrobial Cationic Peptides / pharmacology*
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Bacteria / chemistry
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Bacteria / drug effects*
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Bacteria / immunology*
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Bacterial Infections / drug therapy
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Bacterial Infections / immunology
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Humans
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Lipopolysaccharides / chemistry
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Lipopolysaccharides / immunology*
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Molecular Sequence Data
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NF-kappa B / immunology
Substances
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Anti-Infective Agents
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Anti-Inflammatory Agents
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Antimicrobial Cationic Peptides
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Lipopolysaccharides
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NF-kappa B