Isoflavones with neuroprotective activities from fruits of Cudrania tricuspidata

Phytochemistry. 2015 Mar:111:141-8. doi: 10.1016/j.phytochem.2014.10.021. Epub 2014 Dec 6.

Abstract

Ten isoflavones, cudraisoflavones B-K (1-10), together with 27 known isoflavones, were isolated from the EtOAc soluble extract of fruits of Cudrania tricuspidata. The structures of compounds 1-10 were elucidated on the basis of MS and NMR spectroscopic data, including 2D NMR experiments. Compounds 7-9 and three known (11-13) compounds showed neuroprotective activity against 6-hydroxydopamine induced cell death in human neuroblastoma SH-SY5Y cells, with EC50 values of 0.5-9.2 μM.

Keywords: 6-OHDA; Cudrania tricuspidata; Human neuroblastoma SH-SY5Y; Isoflavones; Moraceae; Neuroprotection; Parkinson’s disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Death / drug effects
  • Fruit / chemistry*
  • Humans
  • Isoflavones / chemistry
  • Isoflavones / isolation & purification*
  • Isoflavones / pharmacology*
  • Molecular Structure
  • Moraceae / chemistry*
  • Neuroprotective Agents / chemistry
  • Neuroprotective Agents / isolation & purification*
  • Neuroprotective Agents / pharmacology*
  • Nuclear Magnetic Resonance, Biomolecular
  • Oxidopamine / pharmacology
  • Plant Roots / chemistry

Substances

  • Isoflavones
  • Neuroprotective Agents
  • Oxidopamine