Rumphellaoic acid A, a novel sesquiterpenoid from the formosan gorgonian coral Rumphella antipathies

Hsu-Ming Chung; Wei-Hsien Wang; Tsong-Long Hwang; Lee-Shing Fang; Zhi-Hong Wen; Jih-Jung Chen; Yang-Chang Wu; Ping-Jyun Sung

doi:10.3390/md12125856

Rumphellaoic acid A, a novel sesquiterpenoid from the formosan gorgonian coral Rumphella antipathies

Mar Drugs. 2014 Dec 4;12(12):5856-63. doi: 10.3390/md12125856.

Authors

Hsu-Ming Chung¹, Wei-Hsien Wang², Tsong-Long Hwang³, Lee-Shing Fang⁴, Zhi-Hong Wen⁵, Jih-Jung Chen⁶, Yang-Chang Wu⁷, Ping-Jyun Sung⁸

Affiliations

¹ Department of Applied Chemistry, National Pingtung University, Pingtung 900, Taiwan. shiuanmin@mail.npue.edu.tw.
² Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. whw@mail.nsysu.edu.tw.
³ Graduate Institute of Natural Products, School of Traditional Medicine, College of Medicine, and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
⁴ Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan. lsfang@csu.edu.tw.
⁵ Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. wzh@mail.nsysu.edu.tw.
⁶ Department of Pharmacy, Tajen University, Pingtung 907, Taiwan. jjchen@tajen.edu.tw.
⁷ School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.
⁸ Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. pjsung@nmmba.gov.tw.

Abstract

A novel sesquiterpenoid, rumphellaoic acid A (1), was isolated from the gorgonian coral Rumphella antipathies, and was found to possess a carbon skeleton that was obtained for the first time from a natural sources. The structure of 1 was elucidated by spectroscopic methods and this compound and was found to exert a moderate inhibitory effect on the release of elastase by human neutrophils.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / chemistry*
Humans
Neutrophils / drug effects
Pancreatic Elastase / metabolism
Sesquiterpenes / chemistry*
Sesquiterpenes / pharmacology*
Spectrum Analysis / methods
Taiwan

Substances

Sesquiterpenes
Pancreatic Elastase