The title compound (trivial name moexipril hydro-chloride) crystallizes as the aceto-nitrile monosolvate, C27H35N2O7 (+)·Cl(-)·C2H3N, with the salt comprising a U-shaped cation and a chloride anion. The conformation of the cation is stabilized by a weak intra-molecular N(+)-H⋯O hydrogen bond and the tetra-hydro-pyridine ring adopts a boat conformation. The dihedral angle between the planes of the benzene rings is 85.6 (1)°. In the crystal, the cations and anions form tight ionic pairs by strong inter-molecular O-H⋯Cl hydrogen bonds. C-H⋯Cl and C-H⋯N hydrogen bonds link these ionic pairs and the aceto-nitrile solvate mol-ecules into puckered layers parallel to (100).
Keywords: crystal structure; hydrogen bond; moexipril hydrochloride.