High field localized proton spectroscopy in small volumes: greatly improved localization and shimming using shielded strong gradients

Magn Reson Med. 1989 May;10(2):256-65. doi: 10.1002/mrm.1910100210.

Abstract

The availability of shielded gradients facilitates accurate single-voxel spectroscopy. Exact localization (90-99%) of volumes as small as 2 x 2 x 2 mm is demonstrated using a modified stimulated echo sequence. Strong gradient pulses (up to 200 mT/m) are employed to clear the stimulated echo of unwanted magnetization, enabling superior (single-scan) shimming of the selected volume. In vivo and in vitro proton NMR results at 4.7 T are presented.

MeSH terms

  • Animals
  • Brain Chemistry*
  • Cats
  • Magnetic Resonance Spectroscopy / methods*
  • Protons

Substances

  • Protons