Patching up broken hearts: cardiac cell therapy gets a bioengineered boost

Vahid Serpooshan; Sean M Wu

doi:10.1016/j.stem.2014.11.008

Patching up broken hearts: cardiac cell therapy gets a bioengineered boost

Cell Stem Cell. 2014 Dec 4;15(6):671-3. doi: 10.1016/j.stem.2014.11.008.

Authors

Vahid Serpooshan¹, Sean M Wu²

Affiliations

¹ Stanford Cardiovascular Institute, Stanford, CA 94305, USA.
² Stanford Cardiovascular Institute, Stanford, CA 94305, USA; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: smwu@stanford.edu.

Abstract

Preclinical and clinical studies for cardiac cell therapy have only seen moderate success due to poor engraftment and survival of transplanted cells. In this issue of Cell Stem Cell, Ye et al. (2014) employ a growth-factor-loaded fibrin patch and show improved cardiovascular cell survival after cell transplantation into a porcine model of ischemia reperfusion.

Publication types

Comment

MeSH terms

Animals
Endothelial Cells / transplantation*
Heart Ventricles / metabolism*
Humans
Induced Pluripotent Stem Cells / physiology*
Myocardial Infarction / therapy*
Myocardium / metabolism*
Myocytes, Cardiac / transplantation*
Myocytes, Smooth Muscle / transplantation*
Stem Cell Transplantation*

Grants and funding

DP1 LM012179/LM/NLM NIH HHS/United States