Abstract
The first total synthesis of the marine polyketide (±)-hippolachnin A has been achieved in nine linear steps and an overall yield of 9%. Rapid access to the oxacyclobutapentalene core structure was secured by strategic application of an ene cyclization.
Keywords:
ene reaction; hippolachnin A; natural products; photochemistry; total synthesis.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalysis
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Coordination Complexes / chemistry
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Cyclization
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Cyclobutanes / chemistry
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Cyclopentanes / chemistry
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Kinetics
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Polyketides / chemical synthesis*
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Polyketides / chemistry
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Rhodium / chemistry
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Stereoisomerism
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Thermodynamics
Substances
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Coordination Complexes
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Cyclobutanes
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Cyclopentanes
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Polyketides
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hippolachnin A
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pentalenene
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Rhodium