[Modern aspects of pathogenesis of the trauma of the spinal cord and trunks of peripheral nerves]

Ross Fiziol Zh Im I M Sechenova. 2014 Feb;100(2):145-60.
[Article in Russian]

Abstract

In pathogenesis of the traumatic disease of the spinal cord, two mechanisms of the injuries of its neuronal apparatus are defined: primary (necrosis) and secondary (apoptosis). In the work a participation of a number of internal causes in the progression of apoptosis in injury of the spinal cord and peripheral nerve trunks, the role of those remains little-studied up to date, is discussed.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Animals
  • Apoptosis / genetics*
  • Caspases / genetics
  • Caspases / metabolism
  • Cytokines / genetics
  • Cytokines / metabolism
  • Gene Expression Regulation
  • Humans
  • Necrosis / genetics
  • Necrosis / metabolism
  • Necrosis / physiopathology*
  • Peripheral Nerve Injuries / genetics
  • Peripheral Nerve Injuries / metabolism
  • Peripheral Nerve Injuries / physiopathology*
  • Peripheral Nerves / metabolism
  • Peripheral Nerves / physiopathology*
  • Proto-Oncogene Proteins c-bcl-2 / genetics
  • Proto-Oncogene Proteins c-bcl-2 / metabolism
  • Reactive Oxygen Species / metabolism
  • Signal Transduction
  • Spinal Cord / metabolism
  • Spinal Cord / physiopathology*
  • Spinal Cord Injuries / genetics
  • Spinal Cord Injuries / metabolism
  • Spinal Cord Injuries / physiopathology*

Substances

  • Cytokines
  • Proto-Oncogene Proteins c-bcl-2
  • Reactive Oxygen Species
  • Caspases