Abstract
Two concise and efficient approaches were developed for the synthesis of α- and δ-carboline derivatives. The success of the synthesis relies on site-selective Suzuki-Miyaura reactions of 1-chloro-2-bromopyridine or 2,3-dibromopyridine with 2-bromophenylboronic acid and subsequent cyclization with amines which proceeds by twofold Pd-catalyzed C-N coupling reactions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Boronic Acids / chemistry
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Carbolines / chemical synthesis*
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Carbolines / chemistry*
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Carbon / chemistry*
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Catalysis
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Chemistry Techniques, Synthetic
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Cyclization
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Models, Molecular
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Molecular Conformation
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Nitrogen / chemistry*
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Palladium / chemistry*
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Pyridines / chemistry
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Substrate Specificity
Substances
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Boronic Acids
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Carbolines
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Pyridines
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Palladium
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Carbon
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Nitrogen