Nerve growth factor receptor immunoreactivity in human benign peripheral nerve sheath tumor

Acta Neuropathol. 1989;77(6):591-8. doi: 10.1007/BF00687886.

Abstract

In situ expression of nerve growth factor (NGF) receptors in human dermal and plexiform neurofibroma, schwannoma and traumatic neuroma was examined by an immunohistochemical method using a monoclonal anti-human NGF receptor antibody. Immunoreactivity for the NGF receptor was observed on the principal cells of both neurofibroma and schwannoma. Immunostaining by the anti-S-100 beta protein antibody in adjacent sections suggested that the vast majority of NGF receptor-positive cells were also positive for S-100 beta protein. In traumatic neuroma, staining for the NGF receptor was more intense in the perineurium than in the endoneurial cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Child
  • Female
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Neoplasms, Nerve Tissue / metabolism*
  • Neurofibroma / metabolism*
  • Peripheral Nervous System Diseases / metabolism*
  • Receptors, Cell Surface / metabolism*
  • Receptors, Nerve Growth Factor

Substances

  • Receptors, Cell Surface
  • Receptors, Nerve Growth Factor