Abstract
Most bacterial chromosomes and plasmids are covalently closed circular molecules that are maintained in a dynamic supercoiled state. Average supercoil density differs significantly between Escherichia coli and Salmonella. Two related questions are: What protein(s) create supercoil domain boundaries in a bacterial chromosome? and How is supercoil density regulated in different bacterial species? RNA polymerase plays pivotal roles in both of these topological phenomena.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Bacteria / genetics
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Bacteria / metabolism
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Catalysis
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Chromosomes, Bacterial / chemistry
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Chromosomes, Bacterial / genetics
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Chromosomes, Bacterial / metabolism
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DNA Gyrase / metabolism
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DNA, Superhelical / genetics
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DNA, Superhelical / metabolism
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DNA-Directed RNA Polymerases / chemistry
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DNA-Directed RNA Polymerases / metabolism*
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Transcription Elongation, Genetic
Substances
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DNA, Superhelical
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DNA-Directed RNA Polymerases
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RNA polymerase alpha subunit
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DNA Gyrase