Neurobiology: Reelin mediates form and function

Tae-Ju Park; Tom Curran

doi:10.1016/j.cub.2014.10.012

Neurobiology: Reelin mediates form and function

Curr Biol. 2014 Nov 17;24(22):R1089-92. doi: 10.1016/j.cub.2014.10.012. Epub 2014 Nov 17.

Authors

Tae-Ju Park¹, Tom Curran²

Affiliations

¹ The Children's Hospital of Philadephia Research Institute, 3501 Civic Center Blvd, Philadelphia, PA 19104, USA. Electronic address: PARKT@email.chop.edu.
² The Children's Hospital of Philadephia Research Institute, 3501 Civic Center Blvd, Philadelphia, PA 19104, USA. Electronic address: currant@email.chop.edu.

PMID: 25458219
DOI: 10.1016/j.cub.2014.10.012

Abstract

Reelin choreographs neuronal migration to establish laminar structures during brain formation. A recent paper uncovers a new function for Reelin signaling in specifying dendritic compartmentalization. Reelin-induced tyrosine phosphorylation is responsible for enrichment of ion channels in dendritic tufts.

Publication types

Comment

MeSH terms

Animals
Cell Adhesion Molecules, Neuronal / metabolism*
Dendrites / metabolism*
Extracellular Matrix Proteins / metabolism*
Nerve Tissue Proteins / metabolism*
Neurons / metabolism*
Serine Endopeptidases / metabolism*

Substances

Cell Adhesion Molecules, Neuronal
Extracellular Matrix Proteins
Nerve Tissue Proteins
Serine Endopeptidases

Grants and funding

R37 NS036558/NS/NINDS NIH HHS/United States