HORMA domains at the heart of meiotic chromosome dynamics

Gerben Vader; Andrea Musacchio

doi:10.1016/j.devcel.2014.11.009

HORMA domains at the heart of meiotic chromosome dynamics

Dev Cell. 2014 Nov 24;31(4):389-91. doi: 10.1016/j.devcel.2014.11.009. Epub 2014 Nov 24.

Authors

Gerben Vader¹, Andrea Musacchio²

Affiliations

¹ Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany. Electronic address: gerben.vader@mpi-dortmund.mpg.de.
² Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany; Centre for Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, 45117 Essen, Germany. Electronic address: andrea.musacchio@mpi-dortmund.mpg.de.

PMID: 25458007
DOI: 10.1016/j.devcel.2014.11.009

Abstract

HORMA domain proteins are required for the careful orchestration of chromosomal organization during meiosis. Kim et al. (2014) and Silva et al. (2014) now provide structural and functional insights into the roles of C. elegans HORMA proteins, revealing parallels to the function of the HORMA protein MAD2 in mitotic checkpoint signaling.

Publication types

Comment

MeSH terms

Animals
Caenorhabditis elegans / metabolism*
Caenorhabditis elegans Proteins / metabolism*
Cell Cycle Proteins / metabolism*
Chromosome Pairing / genetics*
Chromosomes / metabolism*
Meiosis / physiology*
Signal Transduction / physiology*
Synaptonemal Complex / metabolism*

Substances

Caenorhabditis elegans Proteins
Cell Cycle Proteins