Fractional anisotropy in individuals with schizophrenia and their nonpsychotic siblings

Michael P Harms; Kazi D Akhter; John G Csernansky; Susumu Mori; Deanna M Barch

doi:10.1016/j.pscychresns.2014.10.009

Fractional anisotropy in individuals with schizophrenia and their nonpsychotic siblings

Psychiatry Res. 2015 Jan 30;231(1):87-91. doi: 10.1016/j.pscychresns.2014.10.009. Epub 2014 Oct 31.

Authors

Michael P Harms¹, Kazi D Akhter², John G Csernansky³, Susumu Mori², Deanna M Barch⁴

Affiliations

¹ Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: mharms@wustl.edu.
² Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
³ Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
⁴ Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA; Department of Psychology, Washington University, St. Louis, MO, USA.

Abstract

Fractional anisotropy (FA) was examined in a priori selected fiber tracts in individuals with schizophrenia (n=25) and their non-psychotic siblings (n=29) versus controls (n=35). FA was reduced in a portion of the fornix in individuals with schizophrenia (although this did not survive correction for the number of tracts investigated). FA in the siblings did not differ from that in controls in any of the investigated tracts.

Keywords: Diffusion tensor imaging (DTI); Endophenotype; Schizophrenia.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Adult
Anisotropy*
Case-Control Studies
Diffusion Tensor Imaging
Female
Fornix, Brain / pathology*
Humans
Image Processing, Computer-Assisted / methods
Magnetic Resonance Imaging
Male
Schizophrenia / pathology*
Siblings*

Abstract

Publication types

MeSH terms

Grants and funding